Protecting Workers, Saving Lives.

Take Action to Combat Opioid Overdoses in the Workplace

Discover life-saving tools, strategies, and resources to address opioid overdoses in your workplace.

The Opioid Crisis: A Workplace Safety Priority

The opioid crisis poses a growing threat to workplace safety, especially with the rise of fentanyl—a potent synthetic opioid often mixed with other drugs without users’ knowledge.

Naloxone is highly effective in reversing fentanyl overdoses, making it an essential tool for emergency preparedness.

An estimated 12.6% of the U.S. workforce receives an opioid prescription each year[1]. Recent studies also show that 62% of employers report that opioid use is harming the safety of their workplace, and 75% of employers have been impacted by opioids, according to the National Safety Council[2].

Employers play a vital role in the national response, as workplace policies and benefits can shape outcomes in both prevention and recovery. The economic burden is substantial as well—estimated at $179 billion annually—driven by lost productivity, increased healthcare costs, high turnover, and legal risks[3].

Join the Call for Employer Action

What is Naloxone?

Naloxone is a life-saving medication that quickly reverses an opioid overdose. 

It blocks the opioid’s effects and restores normal breathing.

What Employers Can Do Today

  • Place naloxone near first aid kits for quick access.

  • Add naloxone to emergency plans for better preparedness.

  • Train employees to spot and respond to overdoses.

  • Reassure workers: Naloxone is safe, even if no opioids are present.

  • Promote a supportive culture with education and recovery resources.

Implementation Guide: Opioid Overdose Response Program

Resources for the Workplace

Using Naloxone in the Workplace (CDC)

Respond Ready Workplace

Naloxone and the Workplace: Combatting the Opioid Crisis While Safeguarding Workers’ Health and Wellbeing

Narcan Factors to Consider

Alliance for Naloxone Safety in the Workplace

Work Environment Factors and Prevention of Opioid-Related Deaths

Real-World Impact: Saving Lives with Preparedness

Across the country, public and private organizations are proving that preparedness saves lives. These examples highlight how accessible naloxone and training can make an immediate difference:

  • Amazon: Stocking Narcan at warehouses as part of their emergency preparedness strategy.
  • Read Article >>
  • Guilford County, NC: Free naloxone vending machine installed at the Triad Health Project office to increase community access.
  • Read Article >>
  • California: Statewide initiative allows residents to purchase generic naloxone online for just $24 per twin-pack.
  • Read Article >>
  • Laredo, TX: Naloxone distribution and community education campaigns helped reduce overdose deaths by over 50%.
  • Read Article >>
  • Long Island, NY: After losing her son to fentanyl, a mother’s advocacy led local stores to carry Narcan behind the counter.
  • Read Article >>
  • National media coverage: The Washington Post features real-life stories of ordinary individuals using Narcan to save lives in emergency situations.
  • Read Article >>

Join the Workplace Safety Movement - Save Lives at Work

ISEA is committed to supporting employers in addressing this public health crisis. Our organization has responded to the White House’s call to action, is advocating for naloxone in workplace safety kits, and is actively partnering with others to educate employers. ISEA joins leading organizations like SAMHSA, NIOSH, NSC, and OSHA in promoting the availability of naloxone as a critical workplace safety tool. Read More >>

“To help saves lives at work, employers should incorporate overdose prevention into their safety protocols.”
— ISEA President & CEO Cam Mackey

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